Articles of Tributyltin oxide are included as well. TBTO was shown to be hazardous to nontarget organisms. The acute 96-hour LC50 to freshwater fish ranged from 2.6 µg/L to 13 µg/L. CCME (1991 Appendix X) summarised the toxicity data for tributyltin for freshwater animals. Unless otherwise specified, all toxicity and environmental chemistry data presented are for tributyltin oxide, a representative compound. The toxic effects of bis (tributyltin) oxide (TBTO) on the rat liver were studied with an electron microscope and the accumulation sites of tin were determined with an X-ray microanalyzer. Male Wistar rats received an intramuscular injection of 0.5 ml/kg of TBTO. At the initiation of the 3pecial Review there were 364 TBT anti— fouling paint formulations and 20 formulating intermediates with a total of 61 manufacturers. Workers handling dibutyl- and tributyltin have reported eye irritation and skin lesions (1) and mucus irritation after exposure to interior paints containing tin ( 3). Human data summarized by Boyer (1989) suggest that tributyltin oxide is a potent non-allergenic dermal irritant. ------- —2— Registrations: nt.ifoulant paints containing tributyltin (TBT) compounds were initially registered in the early 1960’s. PubMed:Toxicity of tributyltin and triphenyltin to early life-stages of Paracentrotus lividus (Echinodermata: Echinoidea). Tributyltin Compounds. The toxicity of tributyltin oxide to the wood‐boring beetles Lyctus brunneus Steph. Chemical Status Basis Species Parameter Value Units Comments 013356-08-6 Fenbutatin oxide F CrE Rainbow trout LC50: 1.7 ppb/96-hr Fathead minnow LC50: 1.9 ppb/96-hr Daphnid EC50: 3.1 ppb/48-hr Bluegill LC50: 4.8 ppb/96-hr Sheepshead minnow LC50: 20.8 ppb/96-hr In a study of the chronic toxicity of TBT, Brooke et al. There are no data in humans concerning development of cancer following exposure to tributyltin oxide (TBTO). However, the mechanisms underlying TBT-induced central nervous system (CNS) toxicity remain to be determined especially in freshwater aquatic vertebrates. The acute toxicity of tributyltin compounds has been studied on several species of freshwater fish. Because of the questionable data from the bioassay in rats, EPA assigns TBTO to the "cannot be determined" category [U.S. EPA, 1996 (proposed)]. The most sensitive species was the cyprinid Alburnus alburnus with a 96 hr LC50 of 6-8 ugl TBTF. Acute toxicity of bis (tributyltin) oxide in the sweat glands in the rat footpad was investigated by electron microscopy and an energy-dispersive X-ray microanalyzer. Neat tributyltin oxide (TBTO) was purchased from Sigma-Aldrich and used to prepare a Its chemical formula is [ ( Tributyltin oxide (TBTO) is an organotin compound chiefly used as a biocide (fungicide and molluscicide), especially a wood preservative. The effects of tributyltin (TBT) to the life cycle of the estuarine fish Cyprinodon variegatus were examined in a 180-day flow-through exposure. The results showed that TBTO is extremely toxic to O. niloticus with 96 h LC 50 of 16.3 μg L-1 using static renewal bioassay test. Mubychem Group has several manufacturing facilities … Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. The major TBT pesticide is tributyltin oxide. We examined the effect of tributyltin (TBT) on the sex differentiation process in genetically female Japanese flounder (Paralichthys olivaceus).The fish were fed an artificial diet containing tributyltin oxide (TBTO) at concentrations of 0.1 and 1.0 μg/g diet from 35 to 100 d after hatching, which includes the sex differentiation period. These workers also showed that dibutyltin, the major metabolite of tributyltin, is less effective in inducing apoptosis in vitro, suggesting that the in vivo toxicity is directly attributable to tributyltin. PubMed:Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats. PubMed:[Soil sorption of bis-(tributylin) oxide]. The activities of serum enzymes and the concentration of serum bilirubin were also analyzed. STP737 Bioaccumulation and Chronic Toxicity of Bis(tributyltin) Oxide (TBTO): Tests with a Saltwater Fish Based on its review, EPA is now releasing its Reregistration Eligibility Decision (RED) and risk management decision for tributyltin. February 2008 Annals of Applied Biology 60(2):181 - 190 In an inhalation study with tributyltin oxide rats were exposed in nose only chambers for 4 hours 5 days a week for 21 -24 treatments for 29 -32 days. Documents pertaining to 2004 Final Acute and Chronic Ambient Aquatic Life Water Quality Criteria for Tributyltin (TBT) for freshwater and saltwater. and Anobium punctatum (Deg.) Toxicity of Organotins in humans. LC50s range from 6 to 240 ugl TBT. The aim of this study was to assess the acute toxicity of TBT in seawater for the marine copepod T. biminiensis. Previous studies have indicated that TBTO can cause immunotoxicity as an environ-mental pollutant. Comparative toxicity of tributyltin-oxide (TBTO) for fish and snail. Tributyltin oxide (TBTO) is the main constituent of tin-based antifouling marine paint used on the hulls of ships to prevent the growth of fouling organisms. Toxicity values (mean effective concentration [EC50]) ranged from 2.97 to 18.5 μg/L for sperm cells and from 1.11 to 2.62 μg/L for embryos. 1 p. M & T Chemical Co. Jan. 1976. ENVIRONMENTAL TOXICITY DATA FOR CHEMICALS LISTED UNDER EPCRA SECTION 313 CAS NO. Tributyltin oxide (TBTO) is an organotin compound chiefly used as a biocide (fungicide and molluscicide), especially a wood preservative.Its chemical formula is [(C 4 H 9) 3 Sn] 2 O. It is a colorless viscous liquid. (bis)tributyltin oxide, tributyltin benzoate, and tributyltin maleate (collectively known as “tributyltin” or “TBT”). Acute Toxicity of Tributyltin Oxide … 7th World Meeting ORTEP Ass., J.A. The effect of nTiO2 aggregates on the toxicity of the highly toxic marine antifouling compound tributyltin (TBT) to abalone embryos was also investigated. The stingray, Urolophus jamaicensis, may represent the ideal study organism for the adverse effects of TBTO to elasmobranches. The study was initiated with embryos less than 24 h postfertilization and monitored through hatch, maturation, growth, and reproduction under continuous exposure to mean measured TBT concentrations of 5.4, 3.2, 1.3, 0.66, and 0.41 μg TBT/L. Pesticide properties for Tributyltin oxide, including approvals, environmental fate, eco-toxicity and human health issues Toxicity of organotins in humans is most frequently reported as loss of memory and insomnia as well as other symptoms including death ( 4). Tributyltin oxide or Tri Butyl Tin Oxide TBTO Manufacturers, with SDS GHS MSDS Sheet: Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Temmink, J. H. M., & Everts, J. W. (1988). Chemsrc provides Tributyltin oxide(CAS#:56-35-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. After 6-8 h, swelling of mitochondria appeared in the secretory cells of the sweat glands. No developmental effects of nTiO2 were observed at 2 mg/L but concentrations ≥10 mg/L caused hatching inhibition and malformations. TBTO exposure caused serious histological damage to the testis, including reduction in counts of spermatids and spermatozoa and malformation of somatic cells around the seminal duct. We investigated the toxicity of tributyltin oxide (TBTO) on spermatogenesis in a marine fish, mummichog, Fundulus heteroclitus. No information was located regarding toxicity of tributyltin oxide in humans following oral exposure. Tributyltin oxide (TBTO) has been widely used as marine antifouling composition, preservative, biocide, and a stabilizer in plastic industry. These documents include the safe levels of TBT that should protect the majority of species. There are several case reports claiming irritation of the respiratory For sperm cells, the toxicity of the two tributyl compounds was significantly greater than that of two triphenyl compounds; for embryos, the triphenyl compounds appeared to be more toxic. In Proc. It is poorly soluble in water (20 ppm) but highly … Tributyltin oxide - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. The acute inhalation toxicity of Bio-Met-5, bis-tri-n-butyltin-oxide (56359) (Bio-Met-TBTO), tributyltin-fluoride (1983104) (TBTF) and tributyltin-benzoate (4342363) (TBTB) was investigated in Charles-River-rats. Cancer bioassays following oral exposure have been conducted in rats and mice. toxicity in both water and sediment samples (ARAÚJO-CASTRO et al., 2009). The present study was carried out to investigate the acute toxicity of TBTO and the effects of its sublethal concentration on brain AChE and gill ATPases activity of tilapia fish, Oreochromis niloticus during acute (3-96 h) and subchronic (7-28 d) exposure periods. The enclosed Reregistration The Physico-chemical and Physiological Bases of Tributyltin Uptake by Mussels, Mytilus. However, little is known about its reproductive toxicity, Summary of unpublished paper presented at the Fifty Annual.SETAC Meeting; Nov. 4-7, 1984, Arlington, Virginia. 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